Mammaglobin as Molecular Marker of Breast Cancer (Micro)Metastases
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چکیده
منابع مشابه
Human mammaglobin: A specific marker for breast cancer prognosis.
PURPOSE In this study, we examined the expression of human mammaglobin (hMAM) mRNA and the protein levels in patients with breast cancer and their relationship with prognostic clinicopathological parameters. METHODS hMAM mRNA expression in leucocytes from peripheral blood samples from patients diagnosed with primary invasive breast cancer (IC), carcinoma in situ (CIS), or benign breast diseas...
متن کاملMammaglobin a: a promising marker for breast cancer.
prognosis better than approaches using immunohistochemistry or fluorescence in situ hybridization (14 ). Increased serum HER-2/neu was detected in 12% of an overall breast cancer group (15 ) and provided independent prognostic information (12 ) that was superior to that from nodal involvement or hormone receptor status (15 ). Preoperative HER-2/neu concentrations in sera are significantly assoc...
متن کاملIdentification of mammaglobin as a novel serum marker for breast cancer.
PURPOSE Early detection of breast cancer has implications for the management and treatment of patients with this disease. Currently, there exist no highly sensitive and specific serologic biomarkers for detection of breast cancer. Mammaglobin is predicted to be a secreted protein, and expression of this gene seems to be highly specific in breast cancer. The present studies were undertaken to de...
متن کاملMammaglobin, a valuable diagnostic marker for metastatic breast carcinoma.
Identification of metastasis and occult micrometastases of breast cancer demands sensitive and specific diagnostic markers. In this study, we assessed the utility of a mouse monoclonal antibody to human mammaglobin for one such purpose. Immunohistochemical stains were performed on paraffin-embedded sections from a total of 284 cases, which consisted of primary breast invasive carcinomas (41 cas...
متن کاملEvaluation of Nucleostemin Gene Expression as a New Molecular Marker in Breast Tumors
Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2005
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-05-1378